Odontogenic and nonodontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant neoplasms, hamartomas, and other bonerelated lesions that demonstrate great variability in etiology, biologic behavior, and clinical significance. A case of dentigerous cyst in a 9yearold male patient was studied. Introduction a cyst is an epithelium lined sac containing fluid or semifluid material the epithelial cells first proliferate and later undergo degeneration and liquefaction grow by. Three major types of odontogenic cyst are recognizable on the basis of their epithelial derivation, dental relation. Odontogenic cysts and odontogenic tumors in a large rural. Pathogenesis of dental cysts international medical college. This article aims to discuss the clinical features, radiological assessment, histopathology and management of a variety of odontogenic cysts. The glandular odontogenic cyst goc is an uncommon cyst of the jaws, locally aggressive and with recurring potential 1 kramer irh, pindborg jj, shear m, eds. Odontogenic cysts ioannis chatzistefanou, vassilios kogias and.
For each tooth, odontogenesis table 3 begins with the formation. Role of cytokeratin7 in the pathogenesis of odontogenic. The following classification system is a modification of the world health organization. Because the lesion sometimes appears as a solid noncystic lesion, referred to as odontogenic ghost cell tumor, it is no longer classified as one of the odontogenic cysts. Teeth develop from budlike invagination of ectodermal lining of primitive oral cavity epithelium.
Odontogenic keratocyst an overview sciencedirect topics. The cyst encloses the crown of an unerupted tooth by the expansion of its follicle due to a collection of cystic fluid. This article attempts to analyze all cases of odontogenic cysts involving upper jaw. An odontogenic keratocyst is a rare and benign but locally aggressive developmental cyst. Cytokeratins are integral components in tooth development and are expressed across the odontogenic tissues in physiological and pathological states. Review of the molecular pathogenesis of the odontogenic. These are individual lesions which arise from the same odontogenic apparatus but with varying pathogenesis. Odontogenic cysts and tumors ppt linkedin slideshare.
The exact pathogenesis of dentigerous cyst is unknown. Odontogenic keratocyst and keratocystic odontogenic tumour. Mcqs on odontogenic cysts and tumors oral pathology part 2. C botryoid odontogenic cyst gingival cysts c gingival cysts of adults c gingival of infants alveolar cyst glandular odontogenic cyst calcifying odontogenic cyst orthokeratinised odontogenic cyst table 1 figure 1 radicular cyst at the apex of a dead tooth with necrotic pulp. Comparison of components of odontogenic cyst fluids. Radiology of cysts of the jaws columbia university. Calcifying odotogenic cyst is a benign odontogenic tumor of cystic type most likely to affect the anterior areas of the jaws. This is an open access article distributed under the terms of the creative commons attributionnoncommercialsharealike 3.
Pathogenesis and nomenclature of odontogenic carcinomas. Mouth, jaw and face oral and maxillofacial surgeons can treat your jaw tumor or cyst usually by surgery, or in some cases, by medical therapy or a combination of surgery and medical therapy. It is concluded that the dental cyst arises from proliferation of the epithelial rests of malassez in a focus of inflammation stimulated by pulpal necrosis of the associated tooth. Review article pathogenesis and nomenclature of odontogenic carcinomas. Expression of ck14 and vimentin in adenomatoid odontogenic tumor and dentigerous cyst. The possible role of mast cells in the odontogenic cyst s pathogenesis. Adenomatoid odontogenic tumor is a hamartomous benign neoplasia of odontogenic origin. The orthokeratinized odontogenic cyst ooc is a developmental odontogenic cyst relatively rare, arising from the cell rests of the dental lamina. Ptch expression in odontogenic cysts, a cause of pathogenesis or reason for clinical complication. A dentigerous cyst encloses the crown of an unerupted tooth by expansion of its follicle and is attached to the neck of the tooth. Has many features of odontogenic tumor, therefore it is placed in the category of tumors in the latest who classification of odontogenic cysts and tumors.
They almost exclusively occur in permanent dentition. The calcifying odontogenic cyst coc is an uncommon odontogenic lesion with a somewhat wide spectrum of histologic features. Review article pathogenesis and nomenclature of odontogenic. As such the cyst encloses the crown and is attached to the neck at the cementoenamel junction 5. Glandular odontogenic cyst sialo odontogenic cyst very rare pathogenesis of odontogenic cysts cyst formation in the jaws requires three elements. Odontogenic cyst are a group of jaw cysts that are formed from tissues involved in odontogenesis tooth development. Chapter 21 odontogenic and nonodontogenic tumors of the jaws introduction. A dentigerous cyst is formed by the hydrostatic force exerted by the accumulation of fluid between reduced enamel epithelium and the tooth crown of unerupted teeth,5. Cyst formation, like the development of neoplasms, involves a dysregulation of the balance between cell proliferation and cell death. Adenomatoid odontogenic tumor aot is a rare odontogenic tumor which is often misdiagnosed as odontogenic cyst. Revisited swagatikapanda, 1 sujitranjansahoo, 1 gunjansrivastav, 2 subratpadhiary, 3 kanikasinghdhull, 4 andsoniaaggarwal 5 department of oral pathology and microbiology, institute of dental sciences, kalinga nagar, bhubaneswar, india. Inflammatory odontogenic cysts 1 radicular cyst see od1 notes cyst at apex or around root of a nonvital tooth. Jaw tumors and cysts symptoms and causes mayo clinic.
Paradental cyst is an inclusion cyst of the junctionalsulcular epithelium of the gingiva. Pdf the purpose of this study was to determine the prevalence of odontogenic cysts at. Cysts are frequent lesions occurring in the oral cavity and are of much significance because they may be destructive and cause significant signs. Introduction a cyst is an epithelium lined sac containing fluid or semifluid material the epithelial cells first proliferate and later undergo degeneration and liquefaction grow by expansion, causing displacement of adjacent teeth 3. Dec 11, 2018 treatment options for jaw tumors and cysts vary, depending on the type of growth or lesion you have, the stage of growth, and your symptoms. Keratocysts have characteristic locations, the ramus of the mandible, the canine region in the. This study was aimed to evaluate and compare the density of mast cells in dentigerous cyst dc and keratocystic odontogenic tumor kcot regarding their different clinical behavior. The possible role of mast cells in the odontogenic cysts. Inflammation progressing from root apex of carious or necrotic deciduous tooth brings about development of dentigerous cyst around underlying, unerupted permanent tooth. Odontogenic and non odontogenic tumors of the jaws are a relatively rare and heterogeneous group of benign and malignant neoplasms, hamartomas, and other bonerelated lesions that demonstrate great variability in etiology, biologic behavior, and clinical significance. Role of cytokeratin7 in the pathogenesis of odontogenic cysts an. It also highlights the reclassification of odontogenic keratocysts to keratocystic odontogenic tumours.
Factors such as inflammation or trauma stimulate epithelial rests to proliferate sealing off the. Oct 27, 2017 the aneurysmal bone cyst 1 is an even rarer cyst, which occurs in a similar age group and has a similar site distribution to the solitary bone cyst although enlargement of the mandible is a more. The pathogenesis of the three common forms of odontogenic cyst is discussed. Recently, mast cells were recognized in the pathogenesis of more aggressive pathologic lesions. The authors conducted a search in english literature using the following keywords. It appears mostly in young patients and females, the maxillary.
Longstanding chronic inflammation in a periapical granuloma secondary to pulpal necrosis stimulates epithelial proliferation. Induced proliferation of epithelial cell rests rests of serres or malassez in the jaw region plays an important role in the pathogenesis of odontogenic cysts. The cyst is attached to the apex and is composed of an in. The glandular odontogenic cyst is usually asymptomatic and involves the mandible more often than the maxilla. Expression of ck14 and vimentin in adenomatoid odontogenic. Cyst development requires the presence of epithelium in deep tissues and a proliferative stimulus. It is concluded that the dental cyst arises from proliferation of the epithelial rests of malassez in a focus of inflammation stimulated by pulpal necrosis of the associated tootli. It most often affects the posterior mandible and most commonly presents in the third decade of life. Probable growth factors mitogen involved in the pathogenesis of radicular. Odontogenic cysts are distinct entities and quite a common occurrence in the jaw bones. Pdf ptch expression in odontogenic cysts, a cause of. The aneurysmal bone cyst 1 is an even rarer cyst, which occurs in a similar age group and has a similar site distribution to the solitary bone cyst although enlargement of the mandible is a more.
Dec 22, 2016 cysts are frequent lesions occurring in the oral cavity and are of much significance because they may be destructive and cause significant signs and symptoms. Also called as odontogenic ghost cell cyst or gorlin cyst. It is concluded that the dental cyst arises from proliferation of the epithelial rests of malassez in a focus of inflammation stimulated by pulpal necrosis of. Research article the possible role of mast cells in the. Because cystic sp aces within the jaws have special characteristics, they require a more precise definition. Review of the molecular pathogenesis of the odontogenic keratocyst. Comparable changes do not occur in any other region of the body. Cysts and odontogenic neoplasms 160 jaw cysts general features of jaw cysts to physicians, the term cyst means, simply, a space. Chapter 21 odontogenic and non odontogenic tumors of the jaws introduction. Odontogenic cysts of upper jaw an analysis allied academies. Odontogenic cysts are closed sacs, and have a distinct membrane derived from rests of odontogenic epithelium. Odontogenic cysts, tumors, and related jaw lesions preceptor. The dentigerous cysts are odontogenic cysts that are most frequently found in individuals in the age group between 20 and 40 years. A keratocystic odontogenic tumor kot formerly known as an odontogenic keratocyst is a benign cystic tumor of dental origin that probably arises from primitive dental lamina, most commonly occurs in the posterior mandible, and almost certainly represents the lesion that used to be known as a primordial cyst.
The dentigerous cyst arises from pooling of inflammatory exudate, which is derived from the obstructed follicular veins of an unerupted tooth and accumulates. The proliferative activity in the okc was studied by various investigators and it was compared to other odontogenic cysts and tumours. The dentigerous cyst arises from pooling of inflammatory exudate, which is derived frotn the obstructed follicular veins of an unerupted tooth and accumulates. Odontogenic carcinoma is rare group of malignant epithelial odontogenic neoplasms with characteristic clinical behavior and histological features, which requires an aggressive surgical approach. On radiographs, the calcifying odontogenic cyst appears as a unilocular radiolucency dark area. The pathogenesis is similar to a dentigerous cyst in that the epithelium. It is most common in people in their second to third decades but can be seen at almost any age. The most common developmental odontogenic cyst is the dentigerous cyst. Odontogenesis, odontogenic cysts, and odontogenic tumors.
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